Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24253971 | 0.83 | CYP2D6 (0.48) | CYP2D6CYP1A2CYP2C19NPSR1SMN1; SMN2 | |
| SCHEMBL24253970 | 0.79 | CYP2D6 (0.58) | CYP2D6CYP1A2CYP2C19NPSR1SMN1; SMN2 | |
| SCHEMBL24253870 | 0.79 | CYP2D6 (0.56) | CYP2D6CYP1A2CYP2C19NPSR1SMN1; SMN2 | |
| SCHEMBL24254051 | 0.72 | ALDH1A1 (0.46) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL13645932 | 0.71 | CYP1A2 (0.69) | CYP2D6CYP1A2CYP2C19NPSR1SMN1; SMN2 | |
| SCHEMBL21766914 | 0.70 | CYP2D6 (0.65) | CYP2D6CYP1A2CYP2C19NPSR1SMN1; SMN2 | |
| SCHEMBL31323039 | 0.70 | SMN1; SMN2 (0.66) | CYP2D6CYP1A2NPSR1SMN1; SMN2MAPT | |
| SCHEMBL3160275 | 0.70 | HPGD (0.65) | CYP2D6CYP1A2ABL1SMN1; SMN2OPRM1 | |
| SCHEMBL5514832 | 0.70 | HPGD (0.65) | CYP2D6CYP1A2ABL1SMN1; SMN2OPRM1 | |
| SCHEMBL2024169 | 0.70 | HPGD (0.48) | CYP2D6CYP1A2ABL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022034587-A1 | Traf2- AND Nck-INTERACTING KINASE (TNIK) INHIBITORS AND USES THEREOF | TNIK THERAPEUTICS LTD (IL) | 2022-02-17 | — | — | WO | disclosed |