Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1007579 | 0.90 | KMT2A (0.45) | POLBMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL31515782 | 0.90 | KMT2A (0.45) | POLBMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL487103 | 0.86 | MEN1 (0.43) | POLBMEN1KMT2AALDH1A1RXFP1 | |
| SCHEMBL13578846 | 0.86 | POLB (0.44) | POLBMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2157110 | 0.85 | RAB9A (0.53) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL2589170 | 0.85 | ALDH1A1 (0.63) | POLBMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL31372038 | 0.85 | NPC1 (0.46) | POLBMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL2795277 | 0.85 | NPC1 (0.46) | POLBMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL1008033 | 0.84 | RAB9A (0.54) | POLBMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL246277 | 0.84 | AAK1 (0.46) | MEN1KMT2AALDH1A1KDM4EF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022034587-A1 | Traf2- AND Nck-INTERACTING KINASE (TNIK) INHIBITORS AND USES THEREOF | TNIK THERAPEUTICS LTD (IL) | 2022-02-17 | — | — | WO | disclosed |