Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | CFD | P00746 | 1/20 | 0.52 |
| ▸ | RORC | P51449 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | WNT3A | P56704 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254547 | 0.82 | MEN1 (0.58) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL24027877 | 0.79 | MEN1 (0.54) | KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL3714852 | 0.78 | KMT2A (1.00) | KMT2AMEN1SMN1; SMN2CFDRORC | |
| SCHEMBL24254476 | 0.77 | KCNJ6 (0.77) | KMT2AMEN1RORCWNT3AALDH1A1 | |
| SCHEMBL6098738 | 0.77 | CFD (0.81) | KMT2AMEN1SMN1; SMN2CFDUSP2 | |
| SCHEMBL1948079 | 0.77 | KMT2A (0.83) | KMT2AMEN1CFDRORCWNT3A | |
| SCHEMBL253845 | 0.77 | KMT2A (0.72) | KMT2AMEN1SMN1; SMN2CFDRORC | |
| SCHEMBL4300884 | 0.77 | KMT2A (0.72) | KMT2AMEN1SMN1; SMN2CFDRORC | |
| SCHEMBL21242060 | 0.76 | F2R (0.50) | KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4298937 | 0.75 | ALDH1A1 (0.65) | KMT2AMEN1SMN1; SMN2CFDUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |