Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.76 |
| ▸ | NPC1 | O15118 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | GAA | P10253 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.61 |
| ▸ | MITF | O75030 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254585 | 0.96 | HTT (0.74) | HTTNPC1MAPTALDH1A1GAA | |
| SCHEMBL24254530 | 0.85 | NPC1 (0.68) | HTTNPC1MAPTALDH1A1GAA | |
| SCHEMBL26188045 | 0.78 | ALDH1A1 (0.57) | HTTNPC1MAPTALDH1A1GAA | |
| SCHEMBL29452154 | 0.76 | MITF (1.00) | HTTNPC1MAPTALDH1A1GAA | |
| SCHEMBL24254502 | 0.76 | ALDH1A1 (0.66) | HTTMAPTALDH1A1GAAMEN1 | |
| SCHEMBL15010831 | 0.75 | ALDH1A1 (0.73) | HTTMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL24254623 | 0.74 | KCNQ2 (0.53) | HTTNPC1MAPTALDH1A1GAA | |
| SCHEMBL17182984 | 0.73 | MAPT (0.64) | HTTNPC1MAPTALDH1A1GAA | |
| SCHEMBL15276778 | 0.72 | MAPT (0.83) | HTTMAPTALDH1A1GAALMNA | |
| SCHEMBL24254503 | 0.72 | MGAT2 (0.54) | HTTMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |