Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254533 | 0.81 | ALDH1A1 (0.70) | MEN1KMT2ASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL7406083 | 0.75 | MEN1 (0.70) | MEN1KMT2ASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL22491610 | 0.74 | MEN1 (0.69) | MEN1KMT2ASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL16000506 | 0.73 | MEN1 (0.64) | MEN1KMT2ASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL8597349 | 0.71 | POLB (0.55) | MEN1KMT2ASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL8124437 | 0.70 | ALDH1A1 (0.72) | MEN1KMT2AALDH1A1RAB9AGAA | |
| SCHEMBL27014443 | 0.70 | ALDH1A1 (0.61) | POLBALDH1A1RAB9A | |
| SCHEMBL20989280 | 0.70 | MEN1 (0.64) | MEN1KMT2ASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL8290230 | 0.69 | KMT2A (0.69) | MEN1KMT2ASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL16218991 | 0.69 | ALDH1A1 (0.66) | MEN1KMT2ASMN1; SMN2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |