Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | STAT3 | P40763 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 8/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254547 | 0.86 | MEN1 (0.58) | SMN1; SMN2STAT3MEN1KMT2AHTT | |
| SCHEMBL24254543 | 0.84 | MEN1 (0.56) | SMN1; SMN2STAT3MEN1KMT2AHTT | |
| SCHEMBL29079372 | 0.83 | SMN1; SMN2 (0.74) | SMN1; SMN2STAT3MEN1KMT2AHTT | |
| SCHEMBL8269613 | 0.82 | KMT2A (0.65) | SMN1; SMN2MEN1KMT2AHTTMAPT | |
| SCHEMBL24254508 | 0.79 | MEN1 (0.78) | SMN1; SMN2MEN1KMT2AHTTMAPT | |
| SCHEMBL4007599 | 0.78 | MEN1 (0.74) | SMN1; SMN2STAT3MEN1KMT2AHTT | |
| SCHEMBL11679178 | 0.76 | MEN1 (0.77) | SMN1; SMN2STAT3MEN1KMT2AHTT | |
| SCHEMBL28335090 | 0.76 | MEN1 (1.00) | SMN1; SMN2MEN1KMT2AHTTMAPT | |
| SCHEMBL24254505 | 0.76 | LMNA (0.79) | SMN1; SMN2MEN1KMT2AHTTMAPT | |
| SCHEMBL11820160 | 0.75 | MEN1 (0.70) | SMN1; SMN2MEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |