Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254547 | 0.88 | MEN1 (0.58) | MEN1KMT2AMAPTHTTLMNA | |
| SCHEMBL24254549 | 0.84 | SMN1; SMN2 (0.67) | MEN1KMT2AMAPTHTTLMNA | |
| SCHEMBL8269613 | 0.79 | KMT2A (0.65) | MEN1KMT2AMAPTHTTLMNA | |
| SCHEMBL24254506 | 0.76 | KMT2A (0.70) | MEN1KMT2AMAPTHTTLMNA | |
| SCHEMBL24254508 | 0.74 | MEN1 (0.78) | MEN1KMT2AMAPTHTTLMNA | |
| SCHEMBL24254505 | 0.74 | LMNA (0.79) | MEN1KMT2AMAPTHTTLMNA | |
| SCHEMBL24254486 | 0.71 | KMT2A (0.62) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL24254515 | 0.70 | MAPT (0.48) | MEN1KMT2AMAPTHTTLMNA | |
| SCHEMBL24254575 | 0.69 | MAPT (0.53) | MEN1KMT2AMAPTHTTLMNA | |
| SCHEMBL5106834 | 0.69 | NLRP3 (0.62) | MEN1KMT2AHTTLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |