Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | G6PD | P11413 | 1/20 | 0.45 |
| ▸ | IDE | P14735 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 3/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23143746 | 0.87 | G6PD (0.49) | SMN1; SMN2G6PDIDEALDH1A1PTGS2 | |
| SCHEMBL6112909 | 0.85 | CA2 (0.50) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL9980545 | 0.83 | TNNI3K (0.52) | SMN1; SMN2CA1CA2MMP1MMP2 | |
| SCHEMBL17374630 | 0.83 | POLB (0.42) | SMN1; SMN2CA1CA2MMP1MMP2 | |
| SCHEMBL30454747 | 0.80 | KCNH2 (0.46) | SMN1; SMN2PTGS2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL25354604 | 0.80 | KCNH2 (0.46) | SMN1; SMN2PTGS2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3344604 | 0.79 | CA1 (0.65) | SMN1; SMN2G6PDIDECA1CA2 | |
| SCHEMBL18230961 | 0.78 | FFAR4 (0.43) | SMN1; SMN2ALDH1A1PTGS2KCNH2TMEM97 | |
| SCHEMBL28826127 | 0.77 | SMN1; SMN2 (0.40) | SMN1; SMN2KCNH2TMEM97SIGMAR1 | |
| SCHEMBL18230946 | 0.77 | MAPT (0.44) | SMN1; SMN2ALDH1A1PTGS2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |