Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 7/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.44 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.44 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254504 | 0.85 | ALDH1A1 (0.63) | ALDH1A1RAB9ALMNAPOLBGAA | |
| SCHEMBL24254495 | 0.80 | ALDH1A1 (1.00) | ALDH1A1RAB9ALMNAPOLBGAA | |
| SCHEMBL24254500 | 0.80 | ALDH1A1 (0.78) | ALDH1A1RAB9ALMNAGAAPKM | |
| SCHEMBL26188047 | 0.77 | ALDH1A1 (0.67) | ALDH1A1RAB9ALMNAPOLBGAA | |
| SCHEMBL24254509 | 0.76 | ALDH1A1 (0.69) | ALDH1A1RAB9ALMNAGAAPKM | |
| SCHEMBL26188145 | 0.75 | ALDH1A1 (0.64) | ALDH1A1RAB9ALMNAPOLBGAA | |
| SCHEMBL26188049 | 0.75 | ALDH1A1 (0.64) | ALDH1A1RAB9ALMNAGAAPKM | |
| SCHEMBL26188046 | 0.73 | ALDH1A1 (0.58) | ALDH1A1RAB9ALMNAPOLBGAA | |
| SCHEMBL24254501 | 0.73 | CTSD (0.62) | ALDH1A1LMNAGAAPKMCTSD | |
| SCHEMBL24254502 | 0.72 | ALDH1A1 (0.66) | ALDH1A1RAB9ALMNAPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |