Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.52 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.52 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254500 | 0.89 | ALDH1A1 (0.78) | ALDH1A1GAAPKMMAPTNPSR1 | |
| SCHEMBL26188145 | 0.89 | ALDH1A1 (0.64) | ALDH1A1GAAPKMMAPTNPSR1 | |
| SCHEMBL24254509 | 0.87 | ALDH1A1 (0.69) | ALDH1A1GAAPKMMAPTNPSR1 | |
| SCHEMBL26188046 | 0.86 | ALDH1A1 (0.58) | ALDH1A1GAAMAPTNPSR1THRB | |
| SCHEMBL24254587 | 0.85 | ALDH1A1 (0.65) | ALDH1A1GAAPKMRAB9AL3MBTL1 | |
| SCHEMBL24254502 | 0.85 | ALDH1A1 (0.66) | ALDH1A1GAAMAPTNPSR1THRB | |
| SCHEMBL26188047 | 0.83 | ALDH1A1 (0.67) | ALDH1A1GAAPKMMAPTNPSR1 | |
| SCHEMBL24254581 | 0.83 | ALDH1A1 (0.60) | ALDH1A1GAAPKMMAPTNPSR1 | |
| SCHEMBL26188049 | 0.81 | ALDH1A1 (0.64) | ALDH1A1GAAPKMMAPTNPSR1 | |
| SCHEMBL23057067 | 0.81 | ALDH1A1 (0.66) | ALDH1A1GAAPKMMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230271918-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. | 2023-08-31 | — | — | US | disclosed |
| US-20230271918-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. | 2023-08-31 | — | — | US | disclosed |
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230271918-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | USP28, USP30, USP1 | ALDH1A1 1387/4885GAA 607/4885PKM 3685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.