Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | EEF2K | O00418 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24256678 | 0.82 | LMNA (0.67) | SMN1; SMN2LMNAHPGDKMT2AALDH1A1 | |
| SCHEMBL24256858 | 0.69 | MTOR (0.63) | SMN1; SMN2LMNAHPGDKMT2AALDH1A1 | |
| SCHEMBL24256612 | 0.66 | MTOR (0.60) | SMN1; SMN2LMNAHPGDKMT2AALDH1A1 | |
| SCHEMBL24256709 | 0.64 | MTOR (0.61) | SMN1; SMN2LMNAHPGDKMT2AALDH1A1 | |
| SCHEMBL30647980 | 0.64 | DHFR (0.48) | SMN1; SMN2LMNAHPGDCYP1A2BCHE | |
| SCHEMBL7435099 | 0.64 | ATM (0.76) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL24256707 | 0.64 | MTOR (0.58) | SMN1; SMN2LMNAHPGDKMT2AALDH1A1 | |
| SCHEMBL9668420 | 0.64 | ALDH1A1 (0.74) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL11808765 | 0.63 | ATM (0.73) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL11484160 | 0.63 | ALDH1A1 (0.54) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035806-A1 | FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |