Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 1.00 |
| ▸ | HTT | P42858 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.48 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25044302 | 0.75 | PARP1 (0.58) | SMN1; SMN2HTTMAPK1MAPTLMNA | |
| SCHEMBL7455355 | 0.67 | ABCB1 (0.63) | SMN1; SMN2HTTMAPK1MAPTLMNA | |
| SCHEMBL855090 | 0.67 | MAPT (0.78) | SMN1; SMN2HTTMAPTLMNAKMT2A | |
| SCHEMBL7718767 | 0.66 | MAPT (0.59) | SMN1; SMN2HTTMAPTLMNAKMT2A | |
| SCHEMBL3455066 | 0.66 | HTT (0.77) | SMN1; SMN2HTTMAPTLMNAKMT2A | |
| SCHEMBL11488539 | 0.66 | SMN1; SMN2 (0.48) | SMN1; SMN2HTTMAPK1MAPTALDH1A1 | |
| SCHEMBL9930280 | 0.66 | MAPT (0.71) | SMN1; SMN2MAPTLMNAKMT2AALDH1A1 | |
| SCHEMBL27896049 | 0.66 | KDM4E (0.55) | SMN1; SMN2HTTLMNAKMT2AALDH1A1 | |
| SCHEMBL4203087 | 0.66 | PARP1 (0.64) | SMN1; SMN2HTTMAPTLMNAKMT2A | |
| SCHEMBL854589 | 0.65 | MAPT (0.67) | SMN1; SMN2HTTMAPK1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230255970-A1 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATIVE DISEASES | THE BROAD INSTITUTE, INC. (US) | 2023-08-17 | — | — | US | disclosed |
| US-20230255970-A1 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATIVE DISEASES | THE BROAD INSTITUTE, INC. (US) | 2023-08-17 | — | — | US | disclosed |
| US-20230255970-A1 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATIVE DISEASES | THE BROAD INSTITUTE, INC. (US) | 2023-08-17 | — | — | US | disclosed |
| WO-2022036063-A2 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATIVE DISEASES | THE BROAD INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230255970-A1 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATIVE DISEASES | YAP1, RELA, NFKBIA | SMN1; SMN2 1372/4885HTT 2098/4885MAPK1 428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.