Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | VEGFA | P15692 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257584 | 0.90 | MAPK1 (0.39) | GABRA5ADORA1MAPK1MAPK10PTGER1 | |
| SCHEMBL24257575 | 0.89 | ADORA1 (0.37) | ADORA1MAPK1MAPK10PLA2G1BHTT | |
| SCHEMBL30452750 | 0.89 | ADORA1 (0.37) | ADORA1MAPK1MAPK10PLA2G1BHTT | |
| SCHEMBL30453562 | 0.83 | LPAR1 (0.39) | ADORA1MAPK1MAPK10L3MBTL1PTGER1 | |
| SCHEMBL30453138 | 0.83 | GPR119 (0.41) | ADORA1MAPK1MAPK10PTGER1CYP2C9 | |
| SCHEMBL24257587 | 0.83 | LPAR1 (0.39) | ADORA1MAPK1MAPK10L3MBTL1PTGER1 | |
| SCHEMBL24257807 | 0.83 | GPR119 (0.41) | ADORA1MAPK1MAPK10PTGER1CYP2C9 | |
| SCHEMBL30454075 | 0.82 | PTGER1 (0.47) | ADORA1MAPK1MAPK10PTGER1CYP2C9 | |
| SCHEMBL24257585 | 0.82 | PTGER1 (0.47) | ADORA1MAPK1MAPK10PTGER1CYP2C9 | |
| SCHEMBL24257532 | 0.79 | CNR2 (0.48) | ADORA1MAPK1MAPK10L3MBTL1PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036188-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |