Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.36 |
| ▸ | VEGFA | P15692 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.36 |
| ▸ | CTSA | P10619 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257575 | 1.00 | ADORA1 (0.37) | ADORA1MAPK1MAPK10GPR119EGLN1 | |
| SCHEMBL24257587 | 0.91 | LPAR1 (0.39) | ADORA1MAPK1MAPK10GPR119EGLN1 | |
| SCHEMBL30453562 | 0.91 | LPAR1 (0.39) | ADORA1MAPK1MAPK10GPR119EGLN1 | |
| SCHEMBL24257583 | 0.89 | GABRA5 (0.41) | ADORA1MAPK1MAPK10GPR119EGLN1 | |
| SCHEMBL30453138 | 0.86 | GPR119 (0.41) | ADORA1MAPK1MAPK10GPR119EGLN1 | |
| SCHEMBL24257807 | 0.86 | GPR119 (0.41) | ADORA1MAPK1MAPK10GPR119EGLN1 | |
| SCHEMBL30546845 | 0.84 | EGLN1 (0.41) | ADORA1EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL24257527 | 0.84 | EGLN1 (0.41) | ADORA1EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL24257584 | 0.83 | MAPK1 (0.39) | ADORA1MAPK1MAPK10EGLN1VEGFA | |
| SCHEMBL24257585 | 0.80 | PTGER1 (0.47) | ADORA1MAPK1MAPK10GPR119PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116670131-A | PHD inhibitor compounds, compositions, and methods of use | 阿克比治疗有限公司 | 2023-08-29 | — | — | CN | disclosed |
| EP-4196466-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |