Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 7/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | VEGFA | P15692 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.36 |
| ▸ | TET3 | O43151 | 1/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257583 | 0.90 | GABRA5 (0.41) | MAPK1MAPK10ABL1PTGER1CYP2C9 | |
| SCHEMBL30453562 | 0.89 | LPAR1 (0.39) | MAPK1MAPK10PTGER1CYP2C9ADORA1 | |
| SCHEMBL24257587 | 0.89 | LPAR1 (0.39) | MAPK1MAPK10PTGER1CYP2C9ADORA1 | |
| SCHEMBL24257807 | 0.85 | GPR119 (0.41) | MAPK1MAPK10PTGER1CYP2C9ADORA1 | |
| SCHEMBL30453138 | 0.85 | GPR119 (0.41) | MAPK1MAPK10PTGER1CYP2C9ADORA1 | |
| SCHEMBL30452750 | 0.83 | ADORA1 (0.37) | MAPK1MAPK10PTGER1CYP2C9ADORA1 | |
| SCHEMBL24257575 | 0.83 | ADORA1 (0.37) | MAPK1MAPK10PTGER1CYP2C9ADORA1 | |
| SCHEMBL30454075 | 0.83 | PTGER1 (0.47) | MAPK1MAPK10PTGER1CYP2C9ADORA1 | |
| SCHEMBL24257585 | 0.83 | PTGER1 (0.47) | MAPK1MAPK10PTGER1CYP2C9ADORA1 | |
| SCHEMBL24257532 | 0.80 | CNR2 (0.48) | MAPK1MAPK10PTGER1CYP2C9ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036188-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |