Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 4/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.43 |
| ▸ | WNT3A | P56704 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GLP1R | P43220 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24258020 | 1.00 | GPR119 (0.47) | GPR119PARP1PARP2WNT3ACDK9 | |
| SCHEMBL26004922 | 0.84 | ABL1 (0.44) | HDAC6HDAC8 | |
| SCHEMBL24258085 | 0.80 | TLR9 (0.43) | CDK9 | |
| SCHEMBL26004989 | 0.78 | ERCC1 (0.44) | MAPT | |
| SCHEMBL24258081 | 0.77 | ERCC1 (0.45) | HDAC8MAPT | |
| SCHEMBL26006548 | 0.76 | LMNA (0.41) | GSK3BDYRK1AMAPT | |
| SCHEMBL22280443 | 0.71 | HDAC6 (0.49) | GPR119HDAC6HDAC4HDAC8USP30 | |
| SCHEMBL889063 | 0.71 | PTPN2 (0.54) | PARP1PARP2PTPN2PTPN1PTPN6 | |
| SCHEMBL609646 | 0.71 | GPR119 (0.73) | GPR119PTPN2PTPN1PTPN6HDAC6 | |
| SCHEMBL29496349 | 0.71 | SPHK1 (0.50) | GPR119HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035805-A1 | SUBSTITUTED 1,2,4-OXADIAZOLES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |