Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | BMP1 | P13497 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | CLPP | Q16740 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280307 | 0.88 | MAPK1 (0.50) | HDAC6HDAC4HPGDSHDAC8ALDH1A1 | |
| SCHEMBL29522942 | 0.86 | CYP1A2 (0.47) | HDAC6HDAC4HPGDSHDAC8HSD11B1 | |
| SCHEMBL29523928 | 0.86 | SMO (0.47) | HDAC6HDAC4HPGDSHDAC8HSD11B1 | |
| SCHEMBL29522926 | 0.85 | HDAC6 (0.43) | HDAC6HDAC4HPGDSHDAC8HSD11B1 | |
| SCHEMBL29523359 | 0.85 | PIK3CD (0.53) | HDAC6HDAC4HPGDSHDAC8HSD11B1 | |
| SCHEMBL22280559 | 0.85 | LMNA (0.47) | HDAC6HDAC4HPGDSHDAC8HSD11B1 | |
| SCHEMBL29523141 | 0.85 | LMNA (0.47) | HDAC6HDAC4HPGDSHDAC8HSD11B1 | |
| SCHEMBL22280326 | 0.84 | HDAC4 (0.60) | HDAC6HDAC4HSD11B1ALDH1A1GPR119 | |
| SCHEMBL22280590 | 0.84 | LMNA (0.57) | HDAC6HDAC4ALDH1A1GPR119SMN1; SMN2 | |
| SCHEMBL22280276 | 0.84 | LMNA (0.57) | HDAC6HDAC4ALDH1A1GPR119SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |