Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 6/20 | 0.59 |
| ▸ | F10 | P00742 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.44 |
| ▸ | ABAT | P80404 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.39 |
| ▸ | F11 | P03951 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2849627 | 0.83 | MPO (0.39) | LOXL2F10ST14PLAUPRSS1 | |
| SCHEMBL5154706 | 0.83 | LOXL2 (0.59) | LOXL2F10HDAC3HDAC6NCOR2 | |
| Hydrochloric Acid SCHEMBL18300491 | 0.81 | LOXL2 (0.57) | LOXL2F10HDAC3HDAC6NCOR2 | |
| SCHEMBL6960774 | 0.81 | SMN1; SMN2 (0.50) | LOXL2F10PLAUPRSS1PLG | |
| SCHEMBL8363408 | 0.81 | LOXL2 (0.57) | LOXL2F10HDAC3HDAC6NCOR2 | |
| Hydrochloric Acid SCHEMBL6743128 | 0.81 | LOXL2 (0.57) | LOXL2F10HDAC3HDAC6NCOR2 | |
| Hydrochloric Acid SCHEMBL28579848 | 0.79 | LOXL2 (0.55) | LOXL2F10HDAC3HDAC6NCOR2 | |
| SCHEMBL3150195 | 0.78 | LOXL2 (0.56) | LOXL2F10HDAC3HDAC6NCOR2 | |
| SCHEMBL6962838 | 0.78 | PLAU (0.51) | LOXL2PLAUTAAR1 | |
| SCHEMBL6962758 | 0.78 | PLK1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177612-B1 | OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES | NUEVOLUTION AS (DK) | 2022-02-23 | — | — | EP | disclosed |