Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 6/20 | 0.59 |
| ▸ | F10 | P00742 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.59 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.44 |
| ▸ | ABAT | P80404 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.39 |
| ▸ | F11 | P03951 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL18300491 | 0.98 | LOXL2 (0.57) | LOXL2F10HDAC6HDAC3NCOR2 | |
| Hydrochloric Acid SCHEMBL6743128 | 0.98 | LOXL2 (0.57) | LOXL2F10HDAC6HDAC3NCOR2 | |
| SCHEMBL24258314 | 0.83 | LOXL2 (0.59) | LOXL2F10HDAC6HDAC3NCOR2 | |
| SCHEMBL8363408 | 0.81 | LOXL2 (0.57) | LOXL2F10HDAC6HDAC3NCOR2 | |
| SCHEMBL12348299 | 0.81 | HSD17B10 (0.36) | HDAC6HDAC3NCOR2ST14PLAU | |
| SCHEMBL320863 | 0.80 | PRSS1 (0.56) | LOXL2F10HDAC6HDAC3NCOR2 | |
| Hydrochloric Acid SCHEMBL28579848 | 0.79 | LOXL2 (0.55) | LOXL2F10HDAC6HDAC3NCOR2 | |
| SCHEMBL18105627 | 0.78 | HDAC6 (0.35) | LOXL2F10HDAC6HDAC3NCOR2 | |
| SCHEMBL3150195 | 0.78 | LOXL2 (0.56) | LOXL2F10HDAC6HDAC3NCOR2 | |
| SCHEMBL319145 | 0.77 | CA2 (0.46) | HDAC6HDAC3NCOR2ST14PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12187712-B2 | Cardiac sarcomere inhibitors | CYTOKINETICS, INC. (US) | 2025-01-07 | — | — | US | disclosed |
| EP-3814343-B1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS INC (US) | 2023-01-11 | — | — | EP | disclosed |
| EP-3814343-B1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS INC (US) | 2023-01-11 | — | — | EP | disclosed |
| US-20210276991-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. | 2021-09-09 | — | — | US | disclosed |
| US-20210276991-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. | 2021-09-09 | — | — | US | disclosed |
| US-7265220-B2 | Amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative | LES LABORATORIES SERVIER (FR) | 2007-09-04 | — | — | US | disclosed |
| EP-1215213-B1 | Bicyclic amino-pyrazone derivatives, their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2007-01-17 | — | — | EP | disclosed |
| US-20050085517-A1 | Novel amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative | LES LABORATOIRES SERVIER (FR) | 2005-04-21 | — | — | US | disclosed |
| EP-1476421-A2 | NOVEL AMINO ACID DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID DERIVATIVE | LES LABORATOIRES SERVIER (FR) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003070690-A2 | NOVEL AMINO ACID DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID DERIVATIVE | LES LABORATOIRES SERVIER (FR) | 2003-08-28 | — | — | WO | disclosed |
| WO-2003028729-A2 | PRODRUGS OF SUBSTITUTED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |
| EP-1215213-A2 | Bicyclic amino-pyrazone derivatives, their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2002-06-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12187712-B2 | Cardiac sarcomere inhibitors | TNNI3, TNNT2, MYLK2 | LOXL2 1591/4885F10 949/4885HDAC6 233/4885 |
| US-20050085517-A1 | Novel amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative | ARGLU1, PNISR, ATIC | LOXL2 4354/4885F10 1350/4885HDAC6 3648/4885 |
| US-20210276991-A1 | CARDIAC SARCOMERE INHIBITORS | TNNI3, TNNT2, MYLK2 | LOXL2 1591/4885F10 949/4885HDAC6 233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.