Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30853471 | 0.82 | MAPT (0.35) | GAAKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL23930147 | 0.82 | MAPT (0.35) | GAAKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL29403112 | 0.78 | CREBBP (0.50) | CREBBPBRD4EP300 | |
| SCHEMBL17785637 | 0.78 | CREBBP (0.50) | CREBBPBRD4EP300 | |
| SCHEMBL21240848 | 0.76 | ATM (0.34) | GAAKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL31565516 | 0.73 | MAPT (0.31) | GAAKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL31565360 | 0.73 | AR (0.32) | GAAKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL30992903 | 0.73 | CREBBP (0.41) | PDE3BPDE3AGAAKDM4EMAPT | |
| SCHEMBL23930103 | 0.72 | CREBBP (0.39) | CREBBPBRD4EP300 | |
| SCHEMBL30023382 | 0.72 | CREBBP (0.39) | CREBBPBRD4EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464270-B1 | HETEROCYCLIC INHIBITORS OF CBP/EP300 AND THEIR USE IN THE TREATMENT OF CANCER | GENENTECH INC (US) | 2022-02-23 | — | — | EP | disclosed |