Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CETP | P11597 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743474 | 0.94 | MEN1 (0.55) | KMT2AMEN1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL6132298 | 0.93 | MEN1 (0.54) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2943824 | 0.85 | KMT2A (0.61) | KMT2AMEN1MAPTCASP3TRPV1 | |
| SCHEMBL6134434 | 0.81 | ALDH1A1 (0.49) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL24880494 | 0.81 | L3MBTL1 (0.57) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL17543032 | 0.80 | MEN1 (0.52) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL15238296 | 0.80 | ALDH1A1 (0.57) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3795448 | 0.79 | LGMN (0.54) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2941901 | 0.79 | HTT (0.55) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2951762 | 0.79 | HPGD (0.55) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2550258-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbvie Inc. (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119345-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-09-29 | — | — | WO | disclosed |