Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | FGF2 | P09038 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24777174 | 0.77 | MTNR1A (0.56) | KMT2AMEN1HTTSMN1; SMN2HPGD | |
| SCHEMBL20087406 | 0.77 | KMT2A (0.47) | KMT2AMEN1HTTSMN1; SMN2HPGD | |
| SCHEMBL20246935 | 0.76 | MGLL (0.46) | HTTSMN1; SMN2HPGDALDH1A1LMNA | |
| SCHEMBL6897850 | 0.76 | KMT2A (0.49) | KMT2AMEN1HTTSMN1; SMN2HPGD | |
| SCHEMBL24777177 | 0.76 | KMT2A (0.49) | KMT2AMEN1HTTSMN1; SMN2HPGD | |
| SCHEMBL10278649 | 0.74 | KMT2A (0.48) | KMT2AMEN1HTTSMN1; SMN2HPGD | |
| SCHEMBL15934070 | 0.74 | KMT2A (0.35) | KMT2AMEN1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1108308 | 0.73 | MEN1 (0.44) | KMT2AMEN1HTTSMN1; SMN2HPGD | |
| SCHEMBL21389198 | 0.72 | TDP1 (0.46) | KMT2AMEN1HTTSMN1; SMN2HPGD | |
| SCHEMBL31576104 | 0.72 | MEN1 (0.43) | KMT2AMEN1HTTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3432934-B1 | PRODRUGS OF CYTOTOXIC AGENTS WITH ENZYMATICALLY CLEAVABLE GROUPS | Bayer Pharma AG (DE) | 2022-02-23 | — | — | EP | disclosed |