Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 11/20 | 0.67 |
| ▸ | RXRB | P28702 | 7/20 | 0.67 |
| ▸ | RARB | P10826 | 5/20 | 0.67 |
| ▸ | RXRG | P48443 | 5/20 | 0.67 |
| ▸ | RARG | P13631 | 4/20 | 0.67 |
| ▸ | CYP26B1 | Q9NR63 | 7/20 | 0.58 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.58 |
| ▸ | RARA | P10276 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16516895 | 0.86 | CYP26B1 (0.71) | RXRARXRBRARBRXRGRARG | |
| SCHEMBL8733241 | 0.84 | RARB (0.83) | RXRARXRBRARBRXRGRARG | |
| SCHEMBL16516229 | 0.83 | RXRA (0.59) | RXRARXRBRARBRXRGRARG | |
| SCHEMBL10355868 | 0.82 | RXRA (0.65) | RXRARXRBRARBRXRGRARG | |
| SCHEMBL2194599 | 0.80 | RARB (0.82) | RXRARXRBRARBRXRGRARG | |
| SCHEMBL10355871 | 0.80 | RXRA (1.00) | RXRARXRBRARBRXRGRARG | |
| SCHEMBL24259973 | 0.80 | RXRA (0.77) | RXRARXRBRARBRXRGRARG | |
| SCHEMBL2897524 | 0.80 | CYP26B1 (0.53) | RXRARXRBRARBRXRGRARG | |
| SCHEMBL16523407 | 0.79 | RARB (0.74) | RXRARXRBRARBRXRGRARG | |
| SCHEMBL9746493 | 0.78 | RARB (0.71) | RXRARXRBRARBRXRGRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044216-B1 | NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID HYDROXYLASE | UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2022-02-23 | — | — | EP | disclosed |