Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 12/20 | 0.77 |
| ▸ | RARB | P10826 | 11/20 | 0.77 |
| ▸ | RARG | P13631 | 10/20 | 0.77 |
| ▸ | RXRB | P28702 | 9/20 | 0.77 |
| ▸ | RXRG | P48443 | 7/20 | 0.77 |
| ▸ | RARA | P10276 | 8/20 | 0.66 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.66 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8733241 | 0.91 | RARB (0.83) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL10355871 | 0.87 | RXRA (1.00) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL2194599 | 0.87 | RARB (0.82) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL16523407 | 0.85 | RARB (0.74) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL10356129 | 0.83 | CYP26A1 (0.71) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7422927 | 0.83 | RXRA (0.70) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL5540253 | 0.82 | RXRA (0.80) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL9822386 | 0.81 | RXRA (0.68) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL24259975 | 0.80 | CYP26A1 (0.76) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL24259929 | 0.80 | RXRA (0.67) | RXRARARBRARGRXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044216-B1 | NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID HYDROXYLASE | UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2022-02-23 | — | — | EP | disclosed |