Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 6/20 | 0.64 |
| ▸ | RXRA | P19793 | 8/20 | 0.57 |
| ▸ | RXRB | P28702 | 6/20 | 0.57 |
| ▸ | RXRG | P48443 | 6/20 | 0.57 |
| ▸ | RARB | P10826 | 3/20 | 0.57 |
| ▸ | RARG | P13631 | 3/20 | 0.57 |
| ▸ | CYP26B1 | Q9NR63 | 7/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.35 |
| ▸ | LPL | P06858 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2897524 | 0.82 | CYP26B1 (0.53) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL24259972 | 0.82 | CYP26A1 (0.76) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL17911561 | 0.80 | CYP26A1 (0.61) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL24259977 | 0.80 | CYP26B1 (0.67) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL7759680 | 0.79 | RXRA (0.69) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL24259981 | 0.79 | CYP26A1 (0.57) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL17911573 | 0.78 | CYP26A1 (1.00) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL17911584 | 0.76 | CYP26A1 (0.67) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL29567511 | 0.76 | CYP26A1 (0.67) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL577213 | 0.76 | LPL (0.48) | CYP3A4LPLLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044216-B1 | NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID HYDROXYLASE | UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2022-02-23 | — | — | EP | disclosed |