Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 2/20 | 0.57 |
| ▸ | RXRA | P19793 | 10/20 | 0.54 |
| ▸ | RXRB | P28702 | 8/20 | 0.54 |
| ▸ | RXRG | P48443 | 8/20 | 0.54 |
| ▸ | RARB | P10826 | 5/20 | 0.54 |
| ▸ | RARG | P13631 | 4/20 | 0.54 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | RARA | P10276 | 2/20 | 0.37 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7759680 | 0.82 | RXRA (0.69) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL29567380 | 0.82 | CYP26A1 (0.81) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL17911596 | 0.82 | CYP26A1 (0.81) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL1786072 | 0.80 | HTR2C (0.52) | DDB1CRBNHTR2CHTR6TP53 | |
| SCHEMBL17911577 | 0.79 | CYP26A1 (0.60) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL24259952 | 0.79 | CYP26A1 (0.64) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL3176733 | 0.78 | RXRA (0.54) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL29567408 | 0.77 | CYP26A1 (0.55) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL17911601 | 0.77 | CYP26A1 (0.55) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL16516305 | 0.75 | RXRA (0.52) | CYP26A1RXRARXRBRXRGRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044216-B1 | NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID HYDROXYLASE | UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2022-02-23 | — | — | EP | disclosed |