Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.37 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20788437 | 0.81 | NR1H2 (0.59) | NR1H2JAK2JAK1CNR1 | |
| SCHEMBL20788435 | 0.81 | NR1H2 (0.59) | NR1H2JAK2JAK1CNR1 | |
| SCHEMBL20788434 | 0.81 | NR1H2 (0.59) | NR1H2JAK2JAK1CNR1 | |
| SCHEMBL30349470 | 0.80 | GPR119 (0.46) | NR1H2PGRGPR119AR | |
| SCHEMBL23830939 | 0.75 | GPR119 (0.49) | PGRGPR119AR | |
| SCHEMBL24622416 | 0.75 | NR1H2 (0.56) | NR1H2JAK2JAK1GPR119 | |
| SCHEMBL29716428 | 0.75 | NR1H2 (0.56) | NR1H2JAK2JAK1GPR119 | |
| SCHEMBL2573548 | 0.72 | S1PR1 (0.43) | AR | |
| SCHEMBL24267357 | 0.71 | TRPV4 (0.38) | PGRCYP2D6CYP2C9AR | |
| SCHEMBL24985194 | 0.71 | NR1H2 (0.42) | NR1H2GPR119NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3957633-A1 | A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF | Hinova Pharmaceuticals Inc. (CN) | 2022-02-23 | — | — | EP | disclosed |