Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 4/20 | 0.36 |
| ▸ | PGR | P06401 | 5/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 3/20 | 0.33 |
| ▸ | NOS1 | P29475 | 3/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24031511 | 0.77 | PGR (0.47) | TRPV4ARPGRCYP2C19 | |
| SCHEMBL24267226 | 0.74 | TRPV4 (0.44) | TRPV4ARPGR | |
| SCHEMBL24267267 | 0.74 | BCL2A1 (0.41) | TRPV4ARPGRKCNH2KCNJ1 | |
| SCHEMBL24267356 | 0.71 | NR1H2 (0.49) | ARPGRCYP2D6CYP2C9 | |
| SCHEMBL5047623 | 0.70 | TRPV4 (0.52) | TRPV4ARNOS3NOS1CYP11B2 | |
| SCHEMBL7787351 | 0.69 | TRPV4 (0.55) | TRPV4ARKCNH2KCNJ1NOS3 | |
| SCHEMBL15807220 | 0.69 | SLC6A4 (0.54) | KCNH2SLC6A2SLC6A4SLC6A3CYP1A2 | |
| Hydrochloric Acid SCHEMBL6486656 | 0.69 | TRPV4 (0.50) | TRPV4ARNOS3NOS1CYP11B2 | |
| SCHEMBL6928758 | 0.68 | AR (0.42) | ARPGRKCNH2NOS3NOS1 | |
| SCHEMBL5099511 | 0.67 | TRPV4 (0.52) | TRPV4ARKCNH2KCNJ1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3957633-A1 | A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF | Hinova Pharmaceuticals Inc. (CN) | 2022-02-23 | — | — | EP | disclosed |