Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30182911 | 0.87 | MAPT (0.38) | MAPTRXRARXRBRXRGALDH1A1 | |
| SCHEMBL18281904 | 0.85 | GAA (0.41) | MAPTRXRARXRBRXRGALDH1A1 | |
| SCHEMBL767404 | 0.85 | CYP4F2 (0.39) | MAPTRXRARXRBRXRGALDH1A1 | |
| SCHEMBL9904367 | 0.85 | MAPT (0.37) | MAPTRXRARXRBRXRGALDH1A1 | |
| SCHEMBL15744178 | 0.85 | CYP4F2 (0.39) | MAPTRXRARXRBRXRGALDH1A1 | |
| SCHEMBL30615352 | 0.85 | MAPT (0.37) | MAPTRXRARXRBRXRGALDH1A1 | |
| SCHEMBL660435 | 0.82 | ALDH1A1 (0.36) | MAPTRXRARXRBRXRGALDH1A1 | |
| SCHEMBL14800689 | 0.81 | RXRA (0.37) | MAPTRXRARXRBRXRGALDH1A1 | |
| SCHEMBL659294 | 0.81 | ATR (0.38) | MAPTRXRARXRBRXRGALDH1A1 | |
| SCHEMBL23219108 | 0.81 | RXRA (0.39) | MAPTRXRARXRBRXRGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3981766-A1 | INDAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Eisai R&D Management Co., Ltd. (JP) | 2022-04-13 | — | — | EP | disclosed |