Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24273244 | 0.92 | SLC22A12 (0.59) | SLC22A12SMN1; SMN2HDAC1HDAC2CNR1 | |
| SCHEMBL24273327 | 0.91 | KDM4E (0.56) | SLC22A12SMN1; SMN2HDAC1HDAC2CNR1 | |
| SCHEMBL24273335 | 0.90 | HPGD (0.55) | SLC22A12SMN1; SMN2POLBKLKB1TP53 | |
| SCHEMBL24273071 | 0.87 | LMNA (0.56) | SLC22A12SMN1; SMN2HDAC1HDAC2CNR1 | |
| SCHEMBL24273338 | 0.86 | CNR2 (0.56) | SMN1; SMN2HDAC1HDAC2CNR1CNR2 | |
| SCHEMBL24273554 | 0.85 | SMN1; SMN2 (0.62) | SLC22A12SMN1; SMN2HDAC1HDAC2CNR1 | |
| SCHEMBL24273185 | 0.83 | ALDH1A1 (0.50) | SLC22A12SMN1; SMN2HDAC1HDAC2CNR1 | |
| SCHEMBL24273190 | 0.83 | POLB (0.54) | HDAC1HDAC2CNR2POLBTP53 | |
| SCHEMBL24273192 | 0.83 | KDM4E (0.54) | SLC22A12SMN1; SMN2HDAC1CNR1CNR2 | |
| SCHEMBL24273550 | 0.83 | CNR2 (0.56) | SMN1; SMN2HDAC1HDAC2CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022061008-A2 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-03-24 | — | — | WO | disclosed |