Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 5/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901345 | 1.00 | ATM (0.35) | ATMACEAGTR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL15265282 | 0.90 | ALDH1A1 (0.42) | ACEALDH1A1SMN1; SMN2REN | |
| SCHEMBL572684 | 0.86 | ACE (0.36) | ATMACEALDH1A1SMN1; SMN2 | |
| SCHEMBL357830 | 0.84 | ATM (0.34) | ATMACEAGTR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL4024975 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL14343221 | 0.84 | ACE (0.35) | ATMACEALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL14343353 | 0.84 | ACE (0.35) | ATMACEALDH1A1SMN1; SMN2 | |
| Bromide SCHEMBL28148076 | 0.84 | ACE (0.35) | ATMACEALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5473763 | 0.84 | ACE (0.35) | ATMACEALDH1A1SMN1; SMN2 | |
| SCHEMBL30369975 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE43390-E1 | Pleuromutilin derivatives as antimicrobials | GLAXOSMITHKLINE LLC (US) | 2012-05-15 | — | — | US | disclosed |
| EP-1930330-B1 | Pleuromutilin derivatives as antimicrobials | SMITHKLINE BEECHAM LTD (GB) | 2011-09-21 | — | — | EP | disclosed |
| EP-1028961-B3 | PLEUROMUTILIN DERIVATIVES AS ANTIMICROBIALS | SMITHKLINE BEECHAM PLC (GB) | 2008-12-03 | — | — | EP | disclosed |
| EP-1930330-A1 | Pleuromutilin derivatives as antimicrobials | SMITHKLINE BEECHAM PLC (GB) | 2008-06-11 | — | — | EP | disclosed |
| US-RE39128-E1 | ANTIBACTERIA DRUG; RESPIRATORY SYSTEM DISORDERS; OTITIS | SMITHKLINE BEECHAM P.L.C. (GB) | 2006-06-13 | — | — | US | disclosed |
| EP-1028961-B1 | PLEUROMUTILIN DERIVATIVES AS ANTIMICROBIALS | SMITHKLINE BEECHAM PLC (GB) | 2004-09-29 | — | — | EP | disclosed |
| EP-1452534-A1 | PLEUROMUTLIN DERIVATIVES AS ANTIMICROBIALS | SMITHKLINE BEECHAM PLC (GB) | 2004-09-01 | — | — | EP | disclosed |
| US-6281226-B1 | Pleuromutilin derivatives as antimicrobials | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-08-28 | — | — | US | disclosed |