Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 5/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11285930 | 0.86 | SIGMAR1 (0.42) | HTR2CHTR2ASIGMAR1RYR2HTR2B | |
| SCHEMBL23508663 | 0.76 | SIGMAR1 (0.47) | HTR2COPRM1HTR2ASIGMAR1HTR2B | |
| SCHEMBL12481820 | 0.76 | ALDH1A1 (0.37) | HTR2COPRM1HTR2ASIGMAR1HTR2B | |
| Hydrochloric Acid SCHEMBL3492537 | 0.75 | ALDH1A1 (0.36) | HTR2COPRM1HTR2ASIGMAR1HTR2B | |
| SCHEMBL8915121 | 0.71 | HTR2C (0.36) | HTR2COPRM1HTR2ASIGMAR1RYR2 | |
| SCHEMBL8811089 | 0.68 | HTR2A (0.46) | HTR2CHTR2ASIGMAR1RYR2HTR2B | |
| SCHEMBL762112 | 0.67 | TSHR (0.48) | HTR2COPRM1HTR2ADRD2SLC6A2 | |
| SCHEMBL29391638 | 0.67 | TSHR (0.48) | HTR2COPRM1HTR2ADRD2SLC6A2 | |
| Hydrochloric Acid SCHEMBL25400579 | 0.66 | TSHR (0.47) | HTR2COPRM1HTR2ADRD2SLC6A2 | |
| SCHEMBL18828548 | 0.66 | ALDH1A1 (0.52) | HTR2CHTR2ASIGMAR1RYR2HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3984999-A1 | SHP2 PHOSPHATASE ALLOSTERIC INHIBITOR | Beijing Shenogen Pharma Group Ltd. (CN) | 2022-04-20 | — | — | EP | disclosed |