Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 10/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.30 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081930 | 0.73 | MAPK1 (0.38) | ARCNR2MAPK1LRRK2ALDH1A1 | |
| SCHEMBL7213409 | 0.71 | MAPK1 (0.39) | ARCNR2MAPK1FGFR4KDM4E | |
| SCHEMBL15434726 | 0.69 | NOS3 (0.52) | ARMAPK1ALDH1A1KDM4E | |
| SCHEMBL23586637 | 0.69 | MAPK1 (0.38) | ARCNR2MAPK1ALDH1A1FGFR4 | |
| SCHEMBL2202379 | 0.69 | MAPK1 (0.38) | ARCNR2MAPK1ALDH1A1FGFR4 | |
| SCHEMBL24146608 | 0.69 | AR (0.38) | ARTRPV4 | |
| SCHEMBL18443001 | 0.68 | CHEK1 (0.34) | — | |
| SCHEMBL18443352 | 0.67 | HSD11B1 (0.38) | ALDH1A1KDM4ETRPV4 | |
| SCHEMBL16670856 | 0.67 | CNR2 (0.49) | ARCNR2LRRK2FGFR4KDM4E | |
| SCHEMBL20271484 | 0.65 | EGLN2 (0.35) | LRRK2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3555106-B1 | BICYCLIC THIAZINE AND OXAZINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | AMGEN INC (US) | 2022-03-09 | — | — | EP | disclosed |