Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PKLR | P30613 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 8/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.40 |
| ▸ | CPT1A | P50416 | 1/20 | 0.40 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24286236 | 0.84 | PKM (0.52) | POLBKMT2APKMPKLRRORC | |
| SCHEMBL24286256 | 0.82 | CYP3A4 (0.53) | POLBSMN1; SMN2ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL24286304 | 0.82 | NPC1 (0.52) | POLBSMN1; SMN2ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL24286258 | 0.81 | PKM (0.47) | NPC1KMT2APKMPKLRRORC | |
| SCHEMBL24286298 | 0.79 | ALDH1A1 (0.49) | POLBSMN1; SMN2ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL20957419 | 0.79 | RORC (0.57) | RORC | |
| SCHEMBL18312477 | 0.79 | RORC (0.57) | RORC | |
| SCHEMBL24286809 | 0.79 | CYP2C9 (0.51) | POLBSMN1; SMN2ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL20957275 | 0.78 | RORC (0.47) | RORC | |
| SCHEMBL24286787 | 0.78 | RORC (0.46) | POLBCYP3A4CYP2D6MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307738-B1 | ARYL DIHYDRO-2H-BENZO[B][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE | UNIV MICHIGAN REGENTS (US) | 2022-04-20 | — | — | EP | disclosed |