Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24287240 | 0.87 | MAPT (0.42) | HRH4HRH2HRH1HRH3ALDH1A1 | |
| SCHEMBL26813159 | 0.82 | LMNA (0.39) | HRH4HRH2HRH1HRH3ALDH1A1 | |
| SCHEMBL4588982 | 0.72 | HRH4 (0.57) | HRH4HRH2HRH1HRH3ALDH1A1 | |
| SCHEMBL4877642 | 0.72 | BCHE (0.57) | HRH4HRH2HRH1HRH3ALDH1A1 | |
| SCHEMBL24309782 | 0.71 | ADORA2A (0.47) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL26813383 | 0.71 | HTR1A (0.40) | HRH4HRH2HRH1HRH3KDM4E | |
| SCHEMBL2166315 | 0.70 | ALDH1A1 (0.49) | HRH4HRH2HRH1HRH3ALDH1A1 | |
| SCHEMBL4878194 | 0.70 | ALDH1A1 (0.47) | HRH4HRH2HRH1HRH3ALDH1A1 | |
| SCHEMBL602772 | 0.70 | HRH4 (0.47) | HRH4HRH2HRH1HRH3ALDH1A1 | |
| SCHEMBL4876866 | 0.69 | ALDH1A1 (0.46) | HRH4HRH2HRH1HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076629-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |