Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | HPGD | P15428 | 3/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | RELA | Q04206 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | STK17B | O94768 | 2/20 | 0.64 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764640 | 1.00 | KDM4E (0.73) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL214423 | 0.85 | KDM4E (1.00) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL5433929 | 0.85 | KDM4E (1.00) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL214424 | 0.85 | KDM4E (1.00) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL29637244 | 0.85 | KDM4E (1.00) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL10817729 | 0.82 | ALDH1A1 (0.73) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL2431305 | 0.82 | KDM4E (0.73) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL11268973 | 0.82 | KDM4E (1.00) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL4572933 | 0.82 | KDM4E (0.73) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL11275577 | 0.82 | KDM4E (1.00) | KDM4EALDH1A1HPGDL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5066633-A | Sensitizer for heat sensitive paper coatings | GRAPHIC CONTROLS CORPORATION (US) | 1991-11-19 | — | — | US | claimed |
| CN-108752300-B | Benzylidene phenylene peptide compound, pharmaceutical composition and application thereof | 中国科学院昆明植物研究所 | 2022-03-25 | — | — | CN | disclosed |
| CN-108752300-A | Benzyl alkene pitches benzene peptides and its pharmaceutical composition and its application | 中国科学院昆明植物研究所 | 2018-11-06 | — | — | CN | disclosed |
| EP-2215082-B1 | PHTHALAZINE AND PYRIDO[3,4-D]PYRIDAZINE COMPOUNDS AS H1 RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2011-09-21 | — | — | EP | disclosed |
| US-20100216799-A1 | PHTHALAZINE AND PYRIDO[3,4-D]PYRIDAZINE COMPOUNDS AS H1 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | US | disclosed |
| EP-2215082-A1 | PHTHALAZINE AND PYRIDO Ý3,4-D¨PYRIDAZ INE COMPOUNDS AS H1 RECEPTOR ANTAGONISTS | Glaxo Group Limited (GB) | 2010-08-11 | — | — | EP | disclosed |
| US-20100184770-A1 | COMPOUNDS | GLAXO GROUP LIMITED | 2010-07-22 | — | — | US | disclosed |
| EP-2091538-B1 | 4-BENZYL-1(2H)-PHTHALAZINONES AS H1 RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2010-03-03 | — | — | EP | disclosed |
| EP-2091538-A2 | 4-BENZYL-L(2H)-PHTHALAZINONES AS H1 RECEPTOR ANTAGONISTS | Glaxo Group Limited (GB) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009047336-A1 | PHTHALAZINE AND PYRIDO [3,4-D] PYRIDAZ INE COMPOUNDS AS H1 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-04-16 | — | — | WO | disclosed |
| WO-2008074803-A2 | 4-BENZYL-L ( 2H) -PHTHALAZINONES AS H1 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
| US-5066633-A | Sensitizer for heat sensitive paper coatings | GRAPHIC CONTROLS CORPORATION (US) | 1991-11-19 | — | — | US | disclosed |
| US-4841047-A | ANTIALLERGENS | AASTA PHARMA AG (DE) | 1989-06-20 | — | — | US | disclosed |
| EP-0222191-A1 | 4-Benzyl-1-2(H)-phthalazinone derivatives | ASTA Pharma AG (DE) | 1987-05-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216799-A1 | PHTHALAZINE AND PYRIDO[3,4-D]PYRIDAZINE COMPOUNDS AS H1 RECEPTOR ANTAGONISTS | HRH4, HRH2, HRH1 | KDM4E 955/4885ALDH1A1 1732/4885HPGD 281/4885 |
| US-20100184770-A1 | COMPOUNDS | CMA1, TSLP, IL5 | KDM4E 3155/4885ALDH1A1 516/4885HPGD 173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.