Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.41 |
| ▸ | MPL | P40238 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.40 |
| ▸ | FEN1 | P39748 | 2/20 | 0.40 |
| ▸ | IDH2 | P48735 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | SIK1 | P57059 | 1/20 | 0.39 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.39 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24288096 | 0.83 | RPS6KA3 (0.44) | RPS6KA3ALOX5APFEN1KDRMAPK14 | |
| SCHEMBL24288070 | 0.81 | FEN1 (0.50) | MPLALOX5APFEN1 | |
| SCHEMBL24288074 | 0.78 | CYP11B2 (0.36) | CYP11B2CYP11B1 | |
| SCHEMBL27142315 | 0.78 | CHEK1 (0.38) | CYP11B2CYP11B1 | |
| SCHEMBL30838084 | 0.78 | CYP11B1 (0.41) | CYP11B2CYP11B1 | |
| SCHEMBL27095187 | 0.78 | CHEK1 (0.38) | CYP11B2CYP11B1 | |
| SCHEMBL27095188 | 0.78 | CHEK1 (0.38) | CYP11B2CYP11B1 | |
| Hydrochloric Acid SCHEMBL30838031 | 0.77 | CYP11B2 (0.36) | CYP11B2CYP11B1 | |
| Hydrochloric Acid SCHEMBL30838057 | 0.77 | CCNT1 (0.36) | CYP11B2CYP11B1 | |
| Hydrochloric Acid SCHEMBL30838035 | 0.77 | IDH2 (0.48) | IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022053823-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AS NICOTINIC ACETYLCHOLINESTERASE RECEPTOR ALPHA 6 MODULATOR | Cerevance, Inc. (US) | 2022-03-17 | — | — | WO | disclosed |