SCHEMBL242896

SCHEMBL242896

N#C/C(=C\c1ccc(O)c(O)c1)C(N)=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 11/20 1.00
KDM4E B2RXH2 6/20 1.00
MEN1 O00255 6/20 1.00
KMT2A Q03164 6/20 1.00
ERBB2 P04626 6/20 1.00
MAPT P10636 5/20 1.00
TDP1 Q9NUW8 5/20 1.00
ALDH1A1 P00352 5/20 1.00
HPGD P15428 4/20 1.00
CYP1A2 P05177 4/20 1.00
TP53 P04637 3/20 1.00
HSD17B10 Q99714 3/20 1.00
LCK P06239 1/20 1.00
DNM1 Q05193 6/20 0.71
BLM P54132 4/20 0.71
RECQL P46063 3/20 0.71
POLB P06746 3/20 0.71
APEX1 P27695 3/20 0.71
GAA P10253 3/20 0.71
PMP22 Q01453 2/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29357420 1.00 EGFR (1.00) EGFRKDM4EMEN1KMT2AERBB2
SCHEMBL6285299 1.00 EGFR (1.00) EGFRKDM4EMEN1KMT2AERBB2
SCHEMBL1705642 1.00 EGFR (1.00) EGFRKDM4EMEN1KMT2AERBB2
SCHEMBL13060220 0.86 EGFR (0.77) EGFRKDM4EMEN1KMT2AERBB2
SCHEMBL5908882 0.85 EGFR (1.00) EGFRKDM4EMEN1KMT2AERBB2
SCHEMBL29483469 0.85 EGFR (1.00) EGFRKDM4EMEN1KMT2AERBB2
SCHEMBL29357482 0.85 EGFR (1.00) EGFRKDM4EMEN1KMT2AERBB2
SCHEMBL6286665 0.85 EGFR (1.00) EGFRKDM4EMEN1KMT2AERBB2
SCHEMBL17457139 0.85 EGFR (1.00) EGFRKDM4EMEN1KMT2AERBB2
Tyrphostin 47 SCHEMBL5802735 0.83 EGFR (1.00) EGFRKDM4EMEN1KMT2AERBB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 134 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11390600-B2 Crystalline forms of C21H22Cl2N4O2 BIOMED VALLEY DISCOVERIES, INC. (US) 2022-07-19 US claimed
US-20200339531-A1 CRYSTALLINE FORMS OF C21H22Cl2N4O2 VERTEX PHARMACEUTICALS INCORPORATED 2020-10-29 US claimed
US-10738027-B2 Crystalline forms of C21H22Cl2N4O2 BIOMED VALLEY DISCOVERIES, INC. (US) 2020-08-11 US claimed
US-20190127348-A1 CRYSTALLINE FORMS OF C21H22Cl2N4O2 BIOMED VALLEY DISCOVERIES, INC. 2019-05-02 US claimed
EP-0614661-A2 Benzylidene- and cinnamylidine-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1994-09-14 EP claimed
EP-0322738-A2 Benzylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1989-07-05 EP claimed
EP-4662319-A2 PERSONALIZED CRISPR PROFILING FOR CANCER Integrate Bioscience LLC (US) 2025-12-17 EP disclosed
EP-4653054-A2 C. NOVYI FOR THE TREATMENT OF SOLID TUMORS IN HUMANS Biomed Valley Discoveries, Inc. (US) 2025-11-26 EP disclosed
EP-4108248-B1 C. NOVYI FOR THE TREATMENT OF SOLID TUMORS IN HUMANS BIOMED VALLEY DISCOVERIES INC (US) 2025-09-17 EP disclosed
EP-4477222-A2 CRYSTALLINE 4-(5-CHLORO-2-ISOPROPYLAMINOPYRIDIN-4-YL)-1H-PYRROLE-2-CARBOXYLIC ACID [1-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMIDE HYDROCHLORIDE SALT Biomed Valley Discoveries, Inc. (US) 2024-12-18 EP disclosed
EP-3250562-B1 CRYSTALLINE 4-(5-CHLORO-2-ISOPROPYLAMINOPYRIDIN-4-YL)-1H-PYRROLE-2-CARBOXYLIC ACID [1-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMIDE HYDROCHLORIDE SALT BIOMED VALLEY DISCOVERIES INC (US) 2024-11-27 EP disclosed
WO-2024168301-A2 PERSONALIZED CRISPR PROFILING FOR CANCER FUNCTION ONCOLOGY, INC. (US) 2024-08-15 WO disclosed
CN-118141921-A Use of CAMK2 inhibitors for the preparation of a medicament for reducing resistance to EGFR-driven cancers 四川大学 2024-06-07 CN disclosed
US-20060167026-A1 Antipsychotic molecular-targeting epithelial growth factor receptor HIROYUKI NAWA (JP) 2006-07-27 US disclosed
US-RE38761-E1 Styryl compounds which inhibit EGF receptor protein tyrosine kinase YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2005-07-19 US disclosed
EP-0322738-B1 Benzylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells YISSUM RES DEV CO (IL) 1995-04-12 EP disclosed
EP-0614661-A2 Benzylidene- and cinnamylidine-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1994-09-14 EP disclosed
US-5217999-A Antigrowth agents YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1993-06-08 US disclosed
WO-1991016892-A1 STYRYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR PROTEIN TYROSINE KINASE RORER INTERNATIONAL (HOLDINGS), INC. (US) 1991-11-14 WO disclosed
EP-0322738-A2 Benzylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1989-07-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190127348-A1 CRYSTALLINE FORMS OF C21H22Cl2N4O2 CYP2F1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CA4 EGFR 569/4885KDM4E 4194/4885MEN1 63/4885
US-10738027-B2 Crystalline forms of C21H22Cl2N4O2 CYP2F1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CA4 EGFR 569/4885KDM4E 4194/4885MEN1 63/4885
US-20200339531-A1 CRYSTALLINE FORMS OF C21H22Cl2N4O2 CYP2F1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CA4 EGFR 569/4885KDM4E 4194/4885MEN1 63/4885
US-20060167026-A1 Antipsychotic molecular-targeting epithelial growth factor receptor EGFR, BDNF, NTRK2 EGFR 1/4885KDM4E 4214/4885MEN1 4424/4885
US-11390600-B2 Crystalline forms of C21H22Cl2N4O2 CYP2F1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CA4 EGFR 569/4885KDM4E 4194/4885MEN1 63/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.