⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22704533 | 0.90 | POLB (0.31) | — | |
| SCHEMBL22704535 | 0.88 | POLB (0.30) | — | |
| SCHEMBL22704530 | 0.85 | KDM4E (0.36) | — | |
| SCHEMBL22704503 | 0.83 | KDM4E (0.39) | — | |
| SCHEMBL22704497 | 0.82 | — | — | |
| SCHEMBL22704536 | 0.82 | KDM4E (0.34) | — | |
| SCHEMBL22704481 | 0.82 | KDM4E (0.34) | — | |
| SCHEMBL22849851 | 0.82 | NCF1 (0.30) | — | |
| SCHEMBL26370220 | 0.79 | — | — | |
| SCHEMBL22704499 | 0.78 | POLB (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11807636-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2023-11-07 | — | — | US | disclosed |
| EP-3971176-A1 | AROMATIC AMINE AR AND BET TARGETING PROTEIN DEGRADATION CHIMERA COMPOUND AND USE | Hinova Pharmaceuticals Inc. (CN) | 2022-03-23 | — | — | EP | disclosed |