Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.50 |
| ▸ | JAK1 | P23458 | 9/20 | 0.48 |
| ▸ | JAK2 | O60674 | 8/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25833718 | 0.84 | JAK1 (0.48) | KDRJAK1JAK2IKBKBRIPK2 | |
| SCHEMBL26847126 | 0.84 | JAK2 (0.47) | KDRJAK1JAK2IKBKBRIPK2 | |
| SCHEMBL26848583 | 0.80 | JAK2 (0.44) | KDRJAK1JAK2IKBKBRIPK2 | |
| SCHEMBL4283763 | 0.75 | JAK2 (0.52) | KDRJAK1JAK2IKBKBRIPK2 | |
| SCHEMBL24296487 | 0.73 | RIPK1 (0.67) | RIPK1 | |
| SCHEMBL13031280 | 0.73 | JAK1 (0.77) | JAK1JAK2IKBKBRIPK2LCK | |
| SCHEMBL1259412 | 0.73 | KDR (0.54) | KDRJAK1JAK2 | |
| SCHEMBL11916700 | 0.72 | JAK1 (0.69) | JAK1JAK2IKBKBRIPK2LCK | |
| SCHEMBL4286235 | 0.72 | TDP2 (0.53) | KDRJAK1JAK2IKBKBRIPK2 | |
| SCHEMBL42686 | 0.72 | JAK1 (0.64) | JAK1JAK2IKBKBRIPK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4212525-A1 | 5-SUBSTITUTED INDOLE 3-AMIDE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | Origiant Pharmaceutical Co., Ltd (CN) | 2023-07-19 | — | — | EP | disclosed |
| WO-2022052861-A1 | 5-SUBSTITUTED INDOLE 3-AMIDE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | 成都奥睿药业有限公司 | 2022-03-17 | — | — | WO | disclosed |