Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 10/20 | 0.48 |
| ▸ | JAK2 | O60674 | 9/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24296290 | 0.84 | KDR (0.50) | JAK1JAK2KDRIKBKBRIPK2 | |
| SCHEMBL20472534 | 0.82 | AHR (0.48) | JAK2PIK3CDPIK3CGJAK3 | |
| SCHEMBL26847126 | 0.81 | JAK2 (0.47) | JAK1JAK2KDRPIK3CDPIK3CG | |
| SCHEMBL3761195 | 0.81 | PIK3CG (0.49) | PIK3CDPIK3CG | |
| SCHEMBL26848583 | 0.77 | JAK2 (0.44) | JAK1JAK2KDRPIK3CDPIK3CG | |
| SCHEMBL31385125 | 0.77 | RIPK1 (0.46) | — | |
| SCHEMBL26906154 | 0.76 | ABL1 (0.48) | ABL1 | |
| SCHEMBL3912369 | 0.75 | ROCK2 (0.44) | PIK3CDPIK3CG | |
| SCHEMBL4283763 | 0.75 | JAK2 (0.52) | JAK1JAK2KDRIKBKBRIPK2 | |
| SCHEMBL13535387 | 0.75 | JAK1 (0.58) | JAK1JAK2IKBKBRIPK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365546-A1 | 5-SUBSTITUTED INDOLE 3-AMIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | ORIGIANT PHARMACEUTICAL CO., LTD (CN) | 2023-11-16 | — | — | US | disclosed |
| US-20230365546-A1 | 5-SUBSTITUTED INDOLE 3-AMIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | ORIGIANT PHARMACEUTICAL CO., LTD (CN) | 2023-11-16 | — | — | US | disclosed |
| CN-114230565-B | 5-substituted indole 3-amide derivative, preparation method and application thereof | 成都奥睿药业有限公司 | 2023-10-27 | — | — | CN | disclosed |
| EP-4212525-A1 | 5-SUBSTITUTED INDOLE 3-AMIDE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | Origiant Pharmaceutical Co., Ltd (CN) | 2023-07-19 | — | — | EP | disclosed |
| CN-114230565-A | 5-substituted indole 3-amide derivative and preparation method and application thereof | 成都奥睿药业有限公司 | 2022-03-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365546-A1 | 5-SUBSTITUTED INDOLE 3-AMIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | RIPK1, RIPK3, RIPK2 | JAK1 368/4885JAK2 400/4885ABL1 2353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.