Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2429859 | 1.00 | ALDH1A1 (0.43) | ALDH1A1RECQLMMP8CES2ACHE | |
| SCHEMBL2429855 | 0.96 | ALDH1A1 (0.44) | ALDH1A1RECQLMMP8CES2ACHE | |
| SCHEMBL1557733 | 0.90 | ALDH1A1 (0.45) | ALDH1A1RECQLMMP8L3MBTL1PKM | |
| SCHEMBL1557731 | 0.90 | ALDH1A1 (0.45) | ALDH1A1RECQLMMP8L3MBTL1PKM | |
| SCHEMBL1557729 | 0.85 | ALDH1A1 (0.47) | ALDH1A1RECQLMMP8CES2ACHE | |
| SCHEMBL142931 | 0.80 | ALDH1A1 (0.56) | ALDH1A1PKMLMNAMAPTNPSR1 | |
| SCHEMBL3660772 | 0.80 | MAPT (0.38) | ALDH1A1CES2LMNAMAPTKMT2A | |
| SCHEMBL28537382 | 0.80 | THRB (0.42) | ALDH1A1CES2ACHECES1LMNA | |
| SCHEMBL1590184 | 0.79 | ALDH1A1 (0.41) | ALDH1A1RECQLMMP8L3MBTL1LMNA | |
| SCHEMBL1590187 | 0.79 | ALDH1A1 (0.41) | ALDH1A1RECQLMMP8L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026270-B2 | Benzo [F] isoindoles as EP4 receptor agonists | GLAXO GROUP LIMITED (GB) | 2011-09-27 | — | — | US | disclosed |