SCHEMBL2430103

SCHEMBL2430103

Cc1ccc(C(=O)N[C@@H]2[C@@H](O)[C@@H](CO)O[C@@H](S[C@@H]3O[C@H](CO)[C@H](O)[C@@H](NC(=O)c4ccc(C)cc4)[C@H]3O)[C@@H]2O)cc1

nearest known ligand 0.77

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
LGALS3 P17931 11/20 0.77
LGALS9 O00182 6/20 0.77
LGALS1 P09382 6/20 0.77
LGALS7; LGALS7B P47929 5/20 0.77
LGALS8 O00214 2/20 0.66
HK1 P19367 1/20 0.49
HK2 P52789 1/20 0.49
CA1 P00915 7/20 0.46
CA2 P00918 7/20 0.46
CA9 Q16790 7/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2430098 1.00 LGALS3 (0.77) LGALS3LGALS9LGALS1LGALS7; LGALS7BLGALS8
SCHEMBL5450852 0.90 LGALS3 (0.77) LGALS3LGALS9LGALS1LGALS7; LGALS7BLGALS8
SCHEMBL5450848 0.90 LGALS3 (0.77) LGALS3LGALS9LGALS1LGALS7; LGALS7BLGALS8
SCHEMBL2434970 0.88 LGALS3 (0.74) LGALS3LGALS9LGALS1LGALS7; LGALS7BLGALS8
SCHEMBL2432203 0.88 LGALS3 (0.74) LGALS3LGALS9LGALS1LGALS7; LGALS7BLGALS8
SCHEMBL2432200 0.88 LGALS3 (0.74) LGALS3LGALS9LGALS1LGALS7; LGALS7BLGALS8
SCHEMBL17091571 0.88 LGALS3 (0.74) LGALS3LGALS9LGALS1LGALS7; LGALS7BLGALS8
SCHEMBL2434972 0.88 LGALS3 (0.74) LGALS3LGALS9LGALS1LGALS7; LGALS7BLGALS8
SCHEMBL2430861 0.88 LGALS3 (0.77) LGALS3LGALS9LGALS1LGALS7; LGALS7BLGALS8
SCHEMBL2430865 0.88 LGALS3 (0.77) LGALS3LGALS9LGALS1LGALS7; LGALS7BLGALS8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150320782-A1 Methods, compositions and kits for treating, modulating, or preventing ocular angiogenesis or fibrosis in a subject using a galectin protein inhibitor NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-11-12 US claimed
US-20070185039-A1 NOVEL GALACTOSIDE INHIBITORS OF GALECTINS GALECTO BIOTECH AB (SE) 2007-08-09 US claimed
US-20170095496-A1 GALACTOSIDE INHIBITORS FOR NEW USES GALECTO BIOTECH AB (DK) 2017-04-06 US disclosed
US-20150320782-A1 Methods, compositions and kits for treating, modulating, or preventing ocular angiogenesis or fibrosis in a subject using a galectin protein inhibitor NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-11-12 US disclosed
EP-1751171-B1 NOVEL GALACTOSIDE INHIBITORS OF GALECTINS FORSKARPATENT I SYD AB (SE) 2011-09-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150320782-A1 Methods, compositions and kits for treating, modulating, or preventing ocular angiogenesis or fibrosis in a subject using a galectin protein inhibitor LGALS1, LGALS2, LGALS3BP LGALS3 4/4885LGALS9 7/4885LGALS1 1/4885
US-20170095496-A1 GALACTOSIDE INHIBITORS FOR NEW USES LGALS1, LGALS2, LGALS3 LGALS3 3/4885LGALS9 9/4885LGALS1 1/4885
US-20070185039-A1 NOVEL GALACTOSIDE INHIBITORS OF GALECTINS LGALS3, LGALS1, LGALS2 LGALS3 1/4885LGALS9 8/4885LGALS1 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.