Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8583652 | 0.94 | SOAT1 (0.51) | SOAT1MCHR1TSHRLTA4HKCNH2 | |
| SCHEMBL24306122 | 0.87 | SOAT1 (0.47) | SOAT1MCHR1TSHRLTA4HKCNH2 | |
| SCHEMBL2520179 | 0.86 | LTA4H (0.50) | SOAT1MCHR1TSHRLTA4HKCNH2 | |
| SCHEMBL2525163 | 0.84 | MAPK8 (0.56) | MAPK8LTA4HBTKTP53 | |
| SCHEMBL9440291 | 0.84 | MCHR1 (0.44) | SOAT1MCHR1TSHRLTA4HKCNH2 | |
| SCHEMBL24305930 | 0.84 | MCHR1 (0.44) | SOAT1MCHR1TSHRLTA4HKCNH2 | |
| SCHEMBL6001936 | 0.84 | HTR7 (0.45) | SOAT1MCHR1TSHRLTA4HKCNH2 | |
| SCHEMBL8504109 | 0.82 | MCHR1 (0.43) | SOAT1MCHR1TSHRLTA4HKCNH2 | |
| SCHEMBL7083 | 0.82 | HTR7 (0.61) | SOAT1MCHR1TSHRLTA4HKCNH2 | |
| SCHEMBL8903035 | 0.82 | HTR7 (0.61) | SOAT1MCHR1TSHRLTA4HKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119351-A1 | SPIROPIPERIDINE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119351-A1 | SPIROPIPERIDINE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA7, CHRNA5, CHRNA2 | SOAT1 2872/4885MCHR1 583/4885MAPK8 703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.