Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.59 |
| ▸ | ALDH1A3 | P47895 | 8/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM5C | P41229 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22906630 | 0.84 | APP (0.73) | APPALDH1A3CYP11B1CYP11B2NPC1 | |
| SCHEMBL2430718 | 0.82 | APP (0.59) | APPALDH1A3NPC1RAB9AALDH1A1 | |
| SCHEMBL21708014 | 0.80 | ALDH1A3 (0.82) | APPALDH1A3CYP11B1CYP11B2NPC1 | |
| SCHEMBL1691421 | 0.78 | NPC1 (0.75) | APPALDH1A3CYP11B1CYP11B2NPC1 | |
| SCHEMBL2258357 | 0.78 | NPC1 (0.66) | APPALDH1A3CYP11B1CYP11B2NPC1 | |
| SCHEMBL1983592 | 0.78 | APP (0.66) | APPALDH1A3CYP11B1CYP11B2NPC1 | |
| SCHEMBL29438982 | 0.78 | ALDH1A3 (0.79) | APPALDH1A3CYP11B1CYP11B2NPC1 | |
| SCHEMBL2427073 | 0.78 | RAB9A (0.63) | ALDH1A3NPC1RAB9ACLK1DYRK1A | |
| SCHEMBL12380446 | 0.78 | ALDH1A3 (0.75) | APPALDH1A3CYP11B1CYP11B2NPC1 | |
| SCHEMBL989177 | 0.77 | CA12 (0.42) | NPC1RAB9AALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1956013-B1 | DIAGNOSTIC AND REMEDY FOR DISEASE CAUSED BY AMYLOID AGGREGATION AND/OR DEPOSITION | FUJIFILM RI PHARMA CO LTD (JP) | 2016-04-13 | — | — | EP | claimed |
| EP-1956013-B1 | DIAGNOSTIC AND REMEDY FOR DISEASE CAUSED BY AMYLOID AGGREGATION AND/OR DEPOSITION | FUJIFILM RI PHARMA CO LTD (JP) | 2016-04-13 | — | — | EP | disclosed |
| US-8022075-B2 | Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition | FUJIFILM RI PHARMA CO., LTD. (JP) | 2011-09-20 | — | — | US | disclosed |