Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 12/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310709 | 0.91 | DRD2 (0.33) | NPC1PAK1IGF1RDRD2DRD3 | |
| SCHEMBL24310712 | 0.89 | AXL (0.33) | IGF1RDRD2DRD3 | |
| SCHEMBL24310558 | 0.88 | IGF1R (0.31) | PAK1IGF1RDRD2DRD3 | |
| SCHEMBL24310404 | 0.87 | TACR1 (0.33) | IGF1RDRD2DRD3 | |
| SCHEMBL24310089 | 0.87 | DRD2 (0.35) | NPC1PAK1TNIKIGF1RDRD2 | |
| SCHEMBL24309796 | 0.86 | ALK (0.33) | IGF1RDRD2DRD3 | |
| SCHEMBL24309539 | 0.86 | TACR1 (0.32) | IGF1RDRD2DRD3 | |
| SCHEMBL24310417 | 0.86 | LMNA (0.33) | IGF1RCYP1A2CYP2C19 | |
| SCHEMBL24310715 | 0.85 | CSF1R (0.35) | IGF1RPTK2MEN1CYP1A2CYP2C19 | |
| SCHEMBL24309386 | 0.85 | JAK2 (0.37) | IGF1RPTK2MEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |