Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 5/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309386 | 0.92 | JAK2 (0.37) | CSF1REGFRHRH4CTSCMEN1 | |
| SCHEMBL24309916 | 0.88 | EGFR (0.39) | EGFRHRH4CTSCIGF1RMAP4K1 | |
| SCHEMBL24310153 | 0.88 | CTSC (0.36) | EGFRHRH4CTSCIGF1RMAP4K1 | |
| SCHEMBL24309843 | 0.87 | CTSC (0.41) | EGFRHRH4CTSCIGF1RMAP4K1 | |
| SCHEMBL24310686 | 0.86 | BRD4 (0.38) | EGFRHRH4CTSCIGF1RMAP4K1 | |
| SCHEMBL24309899 | 0.85 | NPC1 (0.33) | MEN1KMT2AIGF1RPTK2CYP1A2 | |
| SCHEMBL24310417 | 0.84 | LMNA (0.33) | LMNAIGF1RCYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL29567387 | 0.84 | GPR119 (0.41) | CSF1RJAK2 | |
| SCHEMBL26808857 | 0.84 | GPR119 (0.41) | CSF1RJAK2 | |
| SCHEMBL24309869 | 0.83 | CHEK1 (0.33) | IGF1RMAP4K1CYP1A2CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |