Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310148 | 0.88 | MKNK1 (0.31) | HTR7MKNK1 | |
| SCHEMBL24310557 | 0.86 | DGAT2 (0.32) | — | |
| SCHEMBL24310347 | 0.86 | GPR39 (0.39) | — | |
| SCHEMBL24310563 | 0.85 | HPGD (0.31) | — | |
| SCHEMBL24310142 | 0.84 | GPR39 (0.30) | — | |
| SCHEMBL24310059 | 0.83 | NMT1 (0.37) | HTR7MKNK1 | |
| SCHEMBL29566654 | 0.83 | NMT1 (0.37) | HTR7MKNK1 | |
| SCHEMBL24309561 | 0.83 | KMT2A (0.31) | — | |
| SCHEMBL24310126 | 0.82 | AURKA (0.36) | — | |
| SCHEMBL24309553 | 0.82 | MAP4K1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |