Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.30 |
| ▸ | FLT3 | P36888 | 3/20 | 0.30 |
| ▸ | CSF1R | P07333 | 2/20 | 0.30 |
| ▸ | MET | P08581 | 2/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | FLT4 | P35916 | 1/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310133 | 0.85 | POLB (0.35) | KMT2ASYK | |
| SCHEMBL24310798 | 0.85 | BRD4 (0.33) | KMT2APDE4BMETKDRALDH1A1 | |
| SCHEMBL29566747 | 0.85 | BRD4 (0.33) | KMT2APDE4BMETKDRALDH1A1 | |
| SCHEMBL24310557 | 0.85 | DGAT2 (0.32) | — | |
| SCHEMBL24310126 | 0.84 | AURKA (0.36) | F2MAP4K1ALDH1A1LMNAGLA | |
| SCHEMBL24310060 | 0.83 | HTR7 (0.33) | — | |
| SCHEMBL24310347 | 0.82 | GPR39 (0.39) | KMT2AALDH1A1LMNA | |
| SCHEMBL24310563 | 0.82 | HPGD (0.31) | F2 | |
| SCHEMBL24310105 | 0.81 | BRD4 (0.34) | SYKMAP4K1KDRALDH1A1LMNA | |
| SCHEMBL24310142 | 0.80 | GPR39 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |