Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.37 |
| ▸ | FURIN | P09958 | 4/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309238 | 0.88 | MAP4K1 (0.36) | MAP4K1HRH4BRD4TNK2 | |
| SCHEMBL24310533 | 0.85 | MAP4K1 (0.35) | MAP4K1HRH4 | |
| SCHEMBL24309954 | 0.85 | HTR1D (0.36) | MAP4K1DGAT2HTR1ADRD2HTR2A | |
| SCHEMBL24309872 | 0.85 | CCNA2 (0.40) | BRD4 | |
| SCHEMBL24310347 | 0.85 | GPR39 (0.39) | TNK2 | |
| SCHEMBL24309553 | 0.83 | MAP4K1 (0.31) | MAP4K1 | |
| SCHEMBL24310751 | 0.83 | MAP4K1 (0.34) | MAP4K1HTR1ADRD2HTR2ATNK2 | |
| SCHEMBL24310172 | 0.82 | MAP4K1 (0.36) | MAP4K1KITBRD4 | |
| SCHEMBL29566772 | 0.82 | DGAT2 (0.38) | MAP4K1FURINTNKSDGAT2HTR1A | |
| SCHEMBL26806460 | 0.82 | DGAT2 (0.38) | MAP4K1FURINTNKSDGAT2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |